Fluoro-steroids and processes for their manufacture

Details Fluoro-steroids and processes for their manufacture Fluoro-steroids and processes for their manufacture

1978-02-21

1979-10-23

Love, Ethel G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26039745, 2603975, C07J 7100, C07J 100, C07J 500

Patent

active

041720750

ABSTRACT:
11,12-Unsaturated 9.alpha.-fluorosteroids comprising a new class of steroid compounds are obtained by a novel process, wherein a corresponding 9.alpha.-fluoro-11.beta.-hydroxysteroid is dehydrated with a reagent of the formula F.sub.3 SX in which X denotes an amino group derived from a secondary amine. Of a particular interest among the products of the invention are compounds of the general formula IB ##STR1## in which the symbols R.sub.5 -R.sub.10 have the meanings given hereinafter; such compounds are especially useful as analogues of cortical hormones possessing antiinflammatory activity.

REFERENCES:
patent: 3033749 (1962-05-01), Wettstein et al.
patent: 3621014 (1971-11-01), Stache et al.
patent: 3817988 (1974-06-01), Barton et al.
Euw et al., Helv. Chim. Acta, 29, pp. 654-670, (1946).
Immer et al., Helv. Chim. Acta, 45, pp. 753-770, (1962).

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