Fluoro-prostaglandins and process for their preparation

Details Fluoro-prostaglandins and process for their preparation Fluoro-prostaglandins and process for their preparation

1981-08-14

1984-01-10

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424317, 560118, 562500, C07C17700, A01K 31557

Patent

active

044253591

ABSTRACT:
Fluoro-prostaglandin compounds are disclosed, such as, for instance, 18,19,20-trinor-17-cyclohexyl-16(S,R)-fluoro-PGF.sub.2.alpha.. The fluoro-prostaglandins of the present invention have the same therapeutical uses as natural prostaglandins, but have the advantage of being resistant to the enzyme 15-prostaglandin dehydrogenase, and also exhibit a more selective therapeutical action. Certain of the compounds of the present invention exhibit very favorable luteolytic and antiulcer activity.

REFERENCES:
patent: 3914282 (1975-10-01), Pike
patent: 3932463 (1976-01-01), Schaub
patent: 3933889 (1976-01-01), Magerlin
patent: 3933899 (1976-01-01), Nelson
patent: 3959346 (1976-05-01), Schneider
patent: 3962293 (1976-06-01), Magerlin
patent: 3966792 (1976-06-01), Hayashi
patent: 4152527 (1979-05-01), Hess
Burger, Medicinal Chemistry, pp. 81, 82 (1960).

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