Fluoro analogs of hydrocodone and oxycodone useful as analgesics

Details Fluoro analogs of hydrocodone and oxycodone useful as analgesics Fluoro analogs of hydrocodone and oxycodone useful as analgesics

1979-07-02

1980-12-23

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546 46, A61K 31485, C07D48900

Patent

active

042410657

ABSTRACT:
6-Fluoro analogs of hydrocodone and oxycodone are analgesics and/or narcotic antagonists. Exemplary are 17-cyclopropylmethyl-4,5-epoxy-6,6-difluoro-3-methoxymorphinan and 17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-6-fluoro-3-methoxy- and -3-acetoxymorphinan.

REFERENCES:
patent: 3137701 (1964-06-01), Ayer
patent: 3332950 (1967-07-01), Blumberg et al.
patent: 3393197 (1968-07-01), Pachter et al.
patent: 3928359 (1975-12-01), Walther et al.
patent: 3976691 (1976-08-01), Middleton
patent: 4089855 (1978-05-01), Chatterjie et al.
Somogyi, et al., Chemical Abstracts, vol. 87, 168240y, (1977).
Bognar, et al., Chemical Abstracts, vol. 77, 19840k, (1972).
Makleit, et al., Chemical Abstracts, vol. 77, 152405p, (1972).
Makleit, et al., Chemical Abstracts, vol. 84, 90359k, (1976).
Bognar, et al., Chemical Abstracts, vol. 73, 131174q, (1970).
Yeh, et al., Journal of Pharmaceutical Sciences, vol. 65, No. 6, pp. 902-904, (1976).
Bognar, et al., Acta Chimica Academiae Scientiarum Hungaricae, vol. 67, (1), pp. 63-69, (1971).
Stork, J. Am. Chem. Soc., vol. 78, pp. 4619-4621, (1956).
Somogyi, et al., Acta Chimica Academiae Scientiarum Hungaricae, vol. 97, pp. 339-344, (1978).

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