Fluorine-containing vitamin D.sub.3 analogues and cell different

Details Fluorine-containing vitamin D.sub.3 analogues and cell different Fluorine-containing vitamin D.sub.3 analogues and cell different

1991-06-05

1994-01-11

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

552653, A61K 3159, C07J 700

Patent

active

052781550

ABSTRACT:
Fluorine-containing vitamin D.sub.3 analogues of the formula [I]: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen atom, a chemically inactive hydroxy-protecting group, an acyl having 2 to 8 carbon atoms or an alkyl having 1 to 8 carbon atoms, and n is an integer of 4 to 6, which have excellent pharmacological activities, particularly anti-tumor activity owing to differentiation-inducing activity and are useful for the prophylaxis and treatment of various tumors and intermediates therefore.

REFERENCES:
patent: 4853378 (1989-08-01), Hamma et al.
The Lancet, Colston et al., Jan. 28, 1989, pp. 188-191.
Proc. Natl. Acad. Sci. USA, Ostrem et al., vol. 84, pp. 2610-2614, May 1987.
Bone Mineral Res., Stern et al., vol. 4, 3228, 1989.
Tanaka, et al., Arch. Biochem. Biophys., vol. 29(1), pp. 348-354, Feb. 15, 1984.
Kiriyama, et al., Endocrinology, vol. 128(1), pp. 81-86, 1991.
Inaba, et al., Arch. Biochem Biophys., vol. 268(1), pp. 35-39, Jan. 1989.

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