Fluorine-containing uridine derivative and preparation and use t

Details Fluorine-containing uridine derivative and preparation and use t Fluorine-containing uridine derivative and preparation and use t

1983-12-07

1985-09-17

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536122, C07H 1906

Patent

active

045422095

ABSTRACT:
A fluorine-containing uridine derivative of the formula: ##STR1## wherein R is lower acyl, fluorine-containing lower acyl or fluorine-containing lower alkyl; and X is hydrogen or hydroxyl, which is prepared by a process which comprises fluorinating 2', 3'-O-isopropylideneuridine with fluorine in a solvent selected from the group consisting of lower carboxylic acids, fluorine-containing lower carboxylic acids and fluorine-containing lower alcohols, and is converted to a 5-fluorouridine derivative of the formula: ##STR2## wherein R and X are as defined above by reacting the fluorine-containing uridine derivative of the formula (I) with a base in an organic solvent at a temperature of 0.degree. to 80.degree. C.

REFERENCES:
patent: 3928319 (1975-12-01), Jenkins et al.
patent: 4122251 (1978-10-01), Misaki et al.
patent: 4122252 (1978-10-01), D'Souza et al.

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