Fluorine-containing protoporphyrin derivatives and their salts

Details Fluorine-containing protoporphyrin derivatives and their salts Fluorine-containing protoporphyrin derivatives and their salts

1988-11-04

1990-04-10

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D48722

Patent

active

049162217

ABSTRACT:
Disclosed herein is a fluorine-containing protoporphyrin derivative of formula (I): ##STR1## wherein R.sub.1 and R.sub.2 each independently is --CH.dbd.CH.sub.2 or --CH.dbd.CF.sub.2 with the proviso that R.sub.1 and R.sub.2 cannot both be --CH.dbd.CH.sub.2 ; and salts thereof.
They have remarkable property of peculiarly concentrating or accumulating in the cancer tissues, and very useful as a diagnostic agent of minute cancer in a NMR diagnosis method.

REFERENCES:
H. H. Imhoffen, et al. Justus Liebig's Ann. Chemie, 730, 173, (1969).

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