Fluorine-containing nitroimidazole compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D23391, A61K 31415

Patent

active

053046544

ABSTRACT:
A 2-nitroimidazole compound of the formula: ##STR1## wherein R.sub.f is a fluorine-containing organic group which has at least one fluorine atom on a carbon atom which bonds to the nitrogen atom of the imidazole ring or a carbon atom which bonds to said carbon atom and a radiosensitizer comprising said nitroimidazole derivative.

REFERENCES:
patent: 4371540 (1983-02-01), Lee et al.
patent: 4977273 (1990-11-01), Kagiya et al.
Kagakuno Ryoiki (Chemical Fields), 35, 441 (1981).
Gan to Kagkuryoho, 8, (11), Nov. 1981, p. 1659.
Int. J. Radiat. Biol., 19, 575-585, 1971.
Int. J. Radiat. Biol., 35, 151-160, 1979.
Chemical Abstracts, vol. 107, No. 9, (1987), p. 73465t Mathias et al.
Chemical Abstracts, vol. 89, No. 23, (1978), p. 191005a Rauth et al.
Chemical Abstracts, vol. 89, Chem. Substance Index. I-Po, p. 2720CS.
Chemical Abstracts, vol. 89, No. 23, (1978), p. 191006b Brown et al.
Chemical Abstracts, vol. 105, No. 18, (1986), p. 160447r Jerabeh et al II.
Patent Abstracts of Japan, vol. 11, No. 18 (C-398 [2465], 17h Jan. 1987.
Patent Abstracts of Japan, vol. 9, No. 211 (C-300) [1934], 29th Aug. 1985.
Chemical Abstracts, vol. 105, No. 15, (1986), p. 130194p Raleigh et al.
Chemical Abstracts, 89:191005a, "Testing of hypoxic cell radiosensitizers in vivo", vol. 89, No. 23, Dec. 4, 1978.
Chemical Abstracts, 89:191006b, "In vivo evaluation of the radiosensitizing and cytotoxic properties of newly synthesized electron-affinic drugs", vol. 89, No. 23, Dec. 4, 1978.
Chemical Abstracts, 105:130194p, "Binding of fluorinated 2-nitroimidazoles to spheroids and animal tumors", vol. 105, No. 15, Oct. 13, 1986.
Jerabek et al, "Synthesis and Biodistribution of .sup.18 F-Labeled Fluoronitroimidazoles: Potential in vivo Markers of Hypoxic Tissue", Appl. Radiat. Isot., vol. 37, No. 7, pp. 599-605, 1986.
Shitomoto, et al "Radiosensitization in vitro, etc." CA 105:186742h (1986).
Skorsgard et al, "Radiosensitizatio of Hypoxic, etc" CA 105: 168095v (1986).
Hinchliffe et al, "A Comparision of the, etc" CA 101: 225915f.
Watts et al, "A Comparison of the , etc" CA 107: 194204r (1987).
Workman et al, "Structure/Activity Relationships, etc" CA 98: 83220u (1983).
Sutherland et al I, "Cytotoxicity of Hypoxic, etc" CA 93: 18982b (1980).
Sutherland et al II, "Cytotoxicity of Hypoxic, etc" CA 95: 73188p (1981).
Brown et al I, "Factors Influencing, etc" CA 98: 122128s (1983).
Brown et al II, "Structure-Activity Relationships, etc" CA 96: 213378y (1982).
Takamuki et al, "Glutathione Depletion, etc" CA 109: 186390z (1988).
Reg. No. 117259-20-8.
Reg. No. 81892-69-5.
Reg. No. 81892-68-4.
Reg. No. 74141-75-6.
Reg. No. 22903-73-7.
Reg. No. 74141-74-5.
Reg. No. 22668-03-7.
Reg. No. 22668-01-5.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Fluorine-containing nitroimidazole compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fluorine-containing nitroimidazole compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fluorine-containing nitroimidazole compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-20629

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.