Fluorine containing atrial natriuretic peptides

Details Fluorine containing atrial natriuretic peptides Fluorine containing atrial natriuretic peptides

1988-03-14

1992-03-10

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 530317, 530324, 530325, 530326, A61K 3724, A61K 3702, C07K 710

Patent

active

050950045

ABSTRACT:
Disclosed herein are derivatives of atrial natriuretic peptides which are characterized by having (at position 124 or at positions 106 and 124) a phenylalanyl residue bearing a fluoro or trifluoromethyl substituent on the aromatic portion thereof. Optionally, the exocyclic N-terminal peptide segment and the first cystienyl residue (at position 105) are replaced by an optionally substituted thioalkanoyl residue. The derivatives possess useful diuretic, natriuretic and antihypertensive activities.

REFERENCES:
A. J. De Bold et al., Life Sciences, 28, 89 (1981).
M. Cantin and J. Genest, Endocrine Reviews, 6, 107 (1985).
J. D. Mogannam et al., Abstracts fo the First World Congress on Biologically Active Atrial Peptides, American Society of Hypertension, May 31-Jun. 1, 1986, New York, N.Y., p. 108A.
P. W. Schiller et al., Biochemical and Biophysical Research Communications, 143, 499 (1987).

Affiliated with

Also associated with

Rating

Fluorine containing atrial natriuretic peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fluorine containing atrial natriuretic peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fluorine containing atrial natriuretic peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2284605