Fluorine containing atrial natriuretic peptides

Details Fluorine containing atrial natriuretic peptides Fluorine containing atrial natriuretic peptides

1991-10-23

1994-12-27

Hill, Jr., Robert J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, C07K 710, A61K 3702

Patent

active

053766350

ABSTRACT:
Disclosed herein are derivatives of atrial natriuretic peptides which are characterized by having (at positions 106 and/or 124) a phenylalanyl residue bearing a fluoro or trifluoromethyl substituent on the aromatic portion thereof. Optionally, the exocyclic N-terminal peptide segment and the first cystienyl residue (at position 105) are replaced by an optionally substituted thioalkanoyl residue. The derivatives possess useful diuretic, natriuretic and antihypertensive activities.

REFERENCES:
patent: 5095004 (1992-03-01), Rakhit et al.

Affiliated with

Also associated with

Rating

Fluorine containing atrial natriuretic peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fluorine containing atrial natriuretic peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fluorine containing atrial natriuretic peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-919812