Fluorine-containing antifolates incapable of polyglutamate forma

Details Fluorine-containing antifolates incapable of polyglutamate forma Fluorine-containing antifolates incapable of polyglutamate forma

1984-08-21

1986-04-22

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544260, C07D47508

Patent

active

045843759

ABSTRACT:
A methotrexate derivative having the following general formula is incapable of forming polyglutamate and thus is expected to have reduced cytotoxicity associated with the formation of polyglutamate derivatives in a living cell, ##STR1## wherein n is from 0 to 5.

REFERENCES:
patent: 2741608 (1956-04-01), Shive
patent: 4374987 (1983-02-01), Singh
Burde, "Puti Sin. Izyskaniya Protivoopukholevykh Prep., 1968, 99, pp. 1033-1037.
Bergemann, "Synthesis", (1), 44-46 (1973).
McGuire, Chemical and Engineering News, 62(28), p. 76 (Jul. 9, 1984).

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