Fluorine containing 2,4,5-triphenylimidazoles

Details Fluorine containing 2,4,5-triphenylimidazoles Fluorine containing 2,4,5-triphenylimidazoles

1982-03-10

1984-01-03

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548346, A61K 31415, C07D23356

Patent

active

044242298

ABSTRACT:
Fluorosubstituted benzaldehydes are condensed with anisil and ammonium acetate to yield the corresponding 2-(fluorosubstituted phenyl)-4,5-bis(4-methoxyphenyl)imidazoles. Alternatively fluorosubstituted benzaldehydes are condensed with anisil monoxime and ammonium acetate to yield the corresponding 2-(fluorosubstituted phenyl)-4,5-bis(4-methoxyphenyl)-imidazole-3-oxides which can subsequently be reduced to yield the corresponding 2-(fluorosubstituted phenyl)-4,5-bis(4-methoxyphenyl)imidazoles. These imidazoles have interesting pharmacological properties.

REFERENCES:
patent: 3707475 (1972-12-01), Lombardino et al.
patent: 3784557 (1974-01-01), Cescon
Lombardino et al., Journ. Med. Chem. 1974, vol. 17, No. 11, pp. 1182-1188.

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