Fluorine and chlorine statine or statone containing peptides and

Details Fluorine and chlorine statine or statone containing peptides and Fluorine and chlorine statine or statone containing peptides and

1990-01-18

1991-11-19

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 14, 514 15, 514 16, 514 17, 530326, 530327, 530328, 530329, 530330, A61K 3702, C07K 510, C07K 706, C07K 708

Patent

active

050666436

ABSTRACT:
A peptide optionally in isosteric form wherein a methylene group in the backbone chain is disubstituted, one or both substituents being fluorine and/or chlorine, in free form or in pharmaceutically acceptable salt form, such as a compound of formula I ##STR1## wherein the substituents have various significances, or an isosteric form thereof,
is useful as an enzyme inhibitor. In particular, as a renin inhibitor, it is useful in the prophylaxis or treatment of hypertension and congestive heart failure.
It is prepared by a process comprising the step of coupling two corresponding peptide residues optionally in isosteric form, or precursors thereof, and if required appropriately converting any resultant compound in precursor form.

REFERENCES:
patent: 4518528 (1985-05-01), Rasnick

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