Fluorination with hydrogen fluoride

Details Fluorination with hydrogen fluoride Fluorination with hydrogen fluoride

1989-08-28

1991-03-12

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546345, C07D21361, C07D21384

Patent

active

049994328

ABSTRACT:
Fluoropyridine compounds having a fluoro substituent in at least one of the 2-, 4-, and 6-positions are prepared by treatment of an appropriate 2-, 4-, or 6-chloropyridine compound with excess hydrogen fluoride in a dipolar, aprotic solvent at an elevated temperature and super-atmospheric pressure. Thus, 3,5-dichloro-2,4,6-trifluoropyridine is prepared by heating a mixture of pentachloropyridine, N-methyl-2-pyrrolidinone, and hydrogen fluoride at about 220.degree. C. and about 900 kiloPascals of pressure.

REFERENCES:
patent: 4547577 (1985-11-01), Gatlin et al.
patent: 4590279 (1986-05-01), Fung et al.
patent: 4650875 (1987-03-01), Fujioka
patent: 4680406 (1987-06-01), Fujioka
patent: 4782161 (1988-11-01), DesJardin et al.
patent: 4831148 (1989-05-01), Schurter

Affiliated with

Also associated with

Rating

Fluorination with hydrogen fluoride does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fluorination with hydrogen fluoride, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fluorination with hydrogen fluoride will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-449261