Fluorination of proteins and peptides for F-18 positron...

Details Fluorination of proteins and peptides for F-18 positron... Fluorination of proteins and peptides for F-18 positron...

2005-10-11

2005-10-11

Chan, Christina (Department: 1644)

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

C424S009400, C424S052000, C424S193100, C435S007100, C530S391300, C530S328000

Reexamination Certificate

active

06953567

ABSTRACT:
Thiol-containing peptides can be radiolabeled with fluorine-18 (F-18) by reacting a peptide comprising a free thiol group with an F-18-bound labelling reagent which also has a group that is reactive with thiols. The resulting F-18-labeled peptides may be targeted to a tissue of interest using bispecific antibodies or bispecific antibody fragments having one arm specific for the F-18-labeled peptide or a low molecular weight hapten conjugated to the F-18-labeled peptide, and another arm specific to the targeted tissue. The targeted tissue is subsequently visualized by clinical positron emission tomography.

REFERENCES:
Kuby et al, 1994, Immunology, Second edition, pp. 86-96.
Colman et al, 1994, A structural view of immune recognition by antibodies, pp. 33-36.

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