Fluorination of dicarbonyl compounds

Details Fluorination of dicarbonyl compounds Fluorination of dicarbonyl compounds

2007-08-07

2007-08-07

Puttlitz, Karl (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C570S252000

Reexamination Certificate

active

10505083

ABSTRACT:
The invention provides a method for the preparation of a dicarbonyl compound of formula (I) R1COCFR2COR3wherein R1is selected from alkyl, substituted alkyl, cycloalkyl, aryl, substituted aryl and acetoxy, R2is selected from hydrogen, halogen, nitro, cyano, alkyl, substituted alkyl, cycloalkyl, acetoxy, aryl and substituted aryl, and R3is selected from alkyl, substitued alkyl, oxyalkyl and substituted oxyalkyl, the method comprising treating a dicarbonyl compound of formula (II) R1COCHR2COR3with elemental fluorine in a solvent which consists of methanol or aqueous methanol. The method provides an inexpensive and convenient synthetic route to 2-fluoro- and 2,2-difluoro-1,3-diketones and -1,3-ketoesters.

REFERENCES:
patent: 2003/0036668 (2003-02-01), Bowden et al.
patent: 0 667 332 (1995-08-01), None
patent: 0 781 752 (1997-07-01), None
Inman et al., Reactions of Perchloryl Fluoride with Organic Compounds. II. Fluorination of Certain Active Methylene Compounds, JACS, 80, 6533-5, 1958.
Accession No. 1550479, Beilstein Database (abstract).
Accession No. 3798709, Beilstein Database (abstract).
Accession No. 1051931, Beilstein Database (abstract).
Accession No. 3385783, Beilstein Database (abstract).
Accession No. 3542074, Beilstein Database (abstract).
Accession No. 3744851, Beilstein Database (abstract).
Accession No. 4819692, Beilstein Database (abstract).
Accession No. 1026198, Beilstein Database (abstract).
GB Search Report Corresponding to Application No. GB 0203953.5, date of search Jul. 30, 2002.
Grakauskas “Direct Liquid-Phase Flourination of Aromatic Compounds”Journal of Organic Chemistry35(3): 723-728 (1970).
International Search Report corresponding to International Application No. PCT/GB03/00761, mailed on Jun. 10, 2003.

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