Fluorinated xanthene derivatives

Details Fluorinated xanthene derivatives Fluorinated xanthene derivatives

1996-04-12

2000-12-19

Riley, Jezia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

435 6, 430345, 430915, 430925, 568700, 568707, 544150, 546 41, 549224, 549225, 549226, 549227, C07D31182, C07D31178, C07D31188, C07D47100

Patent

active

061629316

ABSTRACT:
The family of dyes of the invention are fluoresceins and rhodols that are directly substituted on one or more aromatic carbons by fluorine. These fluorine-substituted fluorescent dyes possess greater photostability and have lower sensitivity to pH changes in the physiological range of 6-8 than do non-fluorinated dyes, exhibit less quenching when conjugated to a substance, and possess additional advantages. The dyes of the invention are useful as detectable tracers and for preparing conjugates of organic and inorganic substances.

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