Fluorinated vitamin D.sub.3 compounds

Details Fluorinated vitamin D.sub.3 compounds Fluorinated vitamin D.sub.3 compounds

1984-11-16

1986-09-23

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

2603972, C07J 900

Patent

active

046135944

ABSTRACT:
Novel hexafluoro-cholecalciferol compounds and processes for preparing such compounds are disclosed. Intermediates utilized in the preparation of such compounds and pharmaceutical preparations containing these compounds are also disclosed.

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Shiina, Y. et al. Biological Activity of 24,24-difluoro-1.alpha.,25-dihydroxyvitamin D.sub.3 and 1.alpha.,25-dihydroxyvitamin D.sub.3 -26,23-lactone in Inducing Differentiation of Human Myeloid Leukemia Cells, Arch. Biochem. Biophys. 220: 90-94, 1983.
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Honma, Y. et al. 1.alpha.,25-dihydroxyvitamin D.sub.3 and 1.alpha.-hydroxy Vitamin D.sub.3 Prolong Survival Time of Mice Inoculated with Myeloid Leukemia Cells, Proc. Natl. Acad. Sci. USA 80: 201-204, 1983.
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