Fluorinated Vitamin D.sub.3 analogs

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai

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552653, A61K 3159, C07C40100

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active

058889949

ABSTRACT:
A compound of formula I ##STR1## wherein R is hydrogen, fluorine or hydroxy, and X is .dbd.CH.sub.2 or when R is hydroxy, X is hydrogen or .dbd.CH.sub.2 which are useful in the treatment of hyperproliferative disorders, neoplastic diseases and sebaceous gland diseases.

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Doran, et al. Characterization of Human Cells In Vitro, J. Invest. Dermatol. 96: 34-8 (1991).

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