Fluorinated polyenes

Details Fluorinated polyenes Fluorinated polyenes

1980-05-13

1981-11-10

Siegel, A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568812, 424341, 424346, C07C 4302, C07C 3346, A61K 3109, A61K 3105

Patent

active

042999952

ABSTRACT:
9-substituted, 4- or 6-fluorine substituted retinoic acid derivatives useful as antitumor agents and in the treatment of acne as well as a method for their manufacture are disclosed. Substituents at the 9-position include substituted phenyl, thienyl and furyl groups.

REFERENCES:
patent: 3163669 (1964-12-01), Sills et al.
patent: 3657306 (1972-04-01), Murray
patent: 3883508 (1975-05-01), Cook
patent: 3954817 (1976-05-01), Jager
patent: 3984440 (1976-10-01), Bollag et al.
patent: 4054589 (1977-10-01), Bollag et al.
patent: 4061656 (1977-12-01), Klaus et al.
patent: 4216312 (1978-04-01), Tsuchihashi et al.
Englert, Helv. Chim. Acta, 58:2367-2376 (1975).
Wilkoff et al., Cancer Research, 36:964 (1976).
Chem. Abst. 82:111778x (1975).

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