Fluorinated polyenes

Details Fluorinated polyenes Fluorinated polyenes

1979-05-10

1980-11-04

Niebling, John F.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603473, 2603478, 549 76, 549 78, 549 79, 424275, 424285, C07D30716, C07D30712, C07D33324

Patent

active

042319447

ABSTRACT:
9-substituted, 4- or 6-fluorine substituted retinoic acid derivatives useful as antitumor agents and in the treatment of acne as well as a method for their manufacture are disclosed. Substituents at the 9-position include substituted phenyl, thienyl and furyl groups.

REFERENCES:
patent: 3883508 (1975-05-01), Cook
patent: 3984440 (1976-10-01), Bollag et al.
patent: 4054589 (1977-10-01), Bollag et al.
patent: 4061656 (1977-12-01), Klaus
patent: 4086420 (1978-05-01), Tsuchihashi
Englert Helv. Chim. Acta, 58:2367-2376 (1975).
Wilkoff et al., Cancer Research, 36:964 (1976).

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