Fluorinated glucosamine analogs useful for modulating...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C514S161000, C514S171000, C514S406000, C514S570000, C536S053000, C435S007240

Reexamination Certificate

active

07098195

ABSTRACT:
The present invention provides compositions and methods for inhibiting cell migration, e.g., lymphocytes and inflammation. The invention also provides an improved process for preparing fluorinated N-acetylglucosamines.

REFERENCES:
patent: 5627290 (1997-05-01), Iida et al.
Alon R., et al., “Distinct Cell Surface Ligands Mediate T Lymphocyte Attachment and Rolling on P and E Selectin Under Physiological Flow,”J. Cell Biol. 127(5):1485-1495 (1994).
Berg EL., et al., “The Cutaneous Lymphocyte Antigen is a Skin Lymphocyte Homing Receptor for the Vascular Lectin Endothelial Cell-Leukocyte Adhesion Molecule,”J. Exp. Med.174:1461-1466 (1991).
Bernacki RJ, et al., “Biochemical Characteristics, Metabolism, and Antitumor Activity of Severeral Acetylated Hexosamines,”J. Supramol. Struct. 7(2):235-250 (1977).
Blander JM, et al., “α(1,3)-Fucosyltransferase VII and α(2,3)-Sialyltransferase IV are up-Regulated in Activated CD4 T Cells and Maintained After Their Differentiation Into Th1 and Migration Into Inflammatory Sites,”J. Immunology163(7):3746-3752 (1999).
Borges E., et al., “P-selectin Glycoprotein Ligand-1 (PSGL-1) on T Helper 1 But Not on T Helper 2 Cells Binds to P-Selectin and Supports Migration Into Inflamed Skin,”J. Biol. Chem.272(45):28786-28792 (1997).
Borowitz MJ., et al., “Abnormalities of Circulating T-cell Subpopulations in Patients with Cutaneous T-cell Lymphoma: Cutaneous Lymphocyte-Associated Antigen Expression on T Cells Correlates with Extent of Disease,”Leukemia7(6):859-863 (1993).
Burdick MM, et al., “Glycolipids Support E-selectin-Specific Strong Cell Tethering Under Flow,”Biochem. Biophys. Res. Commun.284(1):42-49 (2001).
Davis RE, et al., “T-Lymphocytes Expressing HECA-452 Epitope are Present in Cutaneous Acute Graft-Versus-Host Disease and Erythema Multiforme, but not in Acute Graft-Versus-Host Disease in Gut Organs,”Amer. J. Path.141(3):691-698 (1992).
Dimitroff CJ, et al., “A Distinct Glycoform of CD44 is an L-Selectin Ligand on Human Hematopoietic Progenitor Cells,”Proc. Natl. Acad. Sci.97(25), 13841-13846 (2000).
Dimitroff CJ, et al., “CD44 is a Major E-Electin Ligand on Human Hematopoietic Progenitor Cells,”J Cell Biol.153:1277-1286 (2001).
Dimitroff CJ, et al., “Differential L-Selectin Binding Activities of Human Hematopoietic Cell L-Selectin Ligands, HCELL and PSGL-1,”J. Biol. Chem.276(50):47623-47631 (2001).
Ellies LG, et al., “Core 2 Oligosaccharide Biosynthesis Distinguishes Between Selectin Ligands Essential for Leukocyte Homing and Inflammation,”Immunity9(6):881-890 (1998).
Erdmann I, et al., “Fucosyltransferase VII-Deficient Mice with Defective E-, P-, and L-Selectin Ligands Show Impaired CD4+ and CD8+ T Cell Migration Into the Skin, But Normal Extravasation Into Visceral Organs.”J. Immunol.168(5):2139-2146 (2002).
Fuhlbrigge RC, et al., “Cutaneous Lymphocyte Antigen is a Specialized Form of PSGL-1 Expressed on Skin-Homing T-Cells,”Nature389:978-981 (1997).
Heald PW, et al., “Skin-Selective Lymphocyte Homing Mechanisms in the Pathogenesis of Leukemic Cutaneous T-Cell Lymphoma,”J. Invest. Dermatol.101(2):222-226 (1993).
Homeister JW, et al., “The α(1,3)Fucosyltransferases FucT-IV and FucT-VII Exert Collaborative Control Over Selectin-Dependent Leukocyte Recruitment and Lymphocyte Homing,”Immunity15(1):115-126 (2001).
Kieffer JD, et al., “Neutrophils, Monocytes, and Dendritic Cells Express the Same Specialized Form of PSGL-1 as Do Skin-Homing Memory T Cells: Cutaneous Lymphocyte Antigen,”Biochem. Biophys. Res. Commun.285(3):577-587 (2001).
Kuan SF, et al., “Inhibition of Mucin GLycosylation by Aryl-N-acetyl-α-galactosamides in Human Colon Cancer Cells,”J. Biol Chem.264(32):19271-19277 (1989).
Kumar R, et al., “Core2 β-1,6-N-Aacetylglucosaminyltransferase Eenzyme Aactivity is Critical for P-Selectin Glycoprotein Ligand-1 Binding to P-Selectin,”Blood88:3872-3879 (1996).
Lowe JB, et al., “ELAM-1-Dependent Cell Adhesion to Vascular Endothelium Determined by a Transfected Human Fucosyltransferase cDNA,”Cell.63(3):475-484 (1990).
Maemura K, et al., “Poly-N-Acetyllactosaminyl O-glycans Attached to Leukosialin. The Presence of Sialyl Le(x) Structures in O-glycans,”J. Biol. Chem.267(34):24379-24386 (1992).
Maly P, et al., “The α(1,3)Fucosyltransferase Fuc-TVII Controls Leukocyte Trafficking Through an Essential Role in L-, E-, and P-Selectin Ligand Biosynthesis,”Cell.86:643-653 (1996).
Mizukawa Y, et al., “Immunohistochemical Detection of Skin-Homing T Cells Expression Fucosyltransferase VII (Fuc-TVII) In Vitro and In Situ,”Lab. Invest.81(5):771-773 (2001).
Moore KL, et al., “The P-Selectin Glycoprotein Ligand From Human Neutrophils Displays Sialylated, Fucosylated, O-linked Poly-N-Acetyllactosamine,”J. Biol. Chem.269(37):23318-23327 (1994).
Nakamura M, et al. “UDP-GlcNAc:Galβ1→3Ga1NAc (GlcNAc to Ga1NAc) β1→6N-Acetylglucosaminyltransferase Holds a Key Role on the Control of CD15s Expression in Human Pre-B Lymphoid Cell Lines,”Glycobiology9(1):1-12 (1999).
Nakayama F, et al., “Expression of Cutaneous Lymphocyte-Associated Antigen Regulated by a Set of Glycosyltransferases in Human T Cells: Involvement of α1, 3-Fucosyltransferase VII and β1,4-Galactosyltransferase I,”J. Invest. Dermatol.115(2):299-306 (2000).
Niemela R, et al., “Complementary Acceptor and Site Specificities of Fuc-TIV and Fuc-TVII Allow Effective Biosynthesis of Sialyl-TriLex and Related Polylactosamines Present on Glycoprotein Counterreceptors of Selectins,”J. Biol. Chem.273(7):4021-4026 (1998).
Okajima T, et al. “Molecular Cloning of a Novel α2,3-Sialyltransferase (ST3Gal VI) That Sialylates Types II Lactosamine Structures on Glycoproteins and Glycolipids,”J. Biol. Chem.274(17):11479-11486 (1999).
Picker LJ, et al., “A Unique Phenotype of Skin-Associated Lymphocytes in Humans. Preferential Expression of the HECA-452 Epitope by Benign and Malignant T cells at Cutaneous Sites,”Amer. J. Path.136:1053-1068 (1990).
Picker LJ, et al., “Control of lymphocyte recirculation in man. II. Differential Regulation of the Cutaneous Lymphocyte-Associated Antigen, a Tissue-Selective Homing Receptor for Skin-Homing T Cells,”J. Immunol.150(3):1122-1136 (1993).
Piller F, et al., “Altered O-Glycan Synthesis in Lymphocytes from Patients with Wiskott-Aldrich Syndrome,”J Exp. Med.173(6):1501-1510 (1991).
Pinola M, et al., “Characterization of the E-Selectin Ligand on NK cells,”J. Immunol.152(7):3586-3594 (1994).
Robert C, et al., “Inflammatory Skin Diseases, T Cells, and Immune Surveillance,”New Engl. J. Med.341(24):1817-1828 (1999).
Rook AH, et al., “The Immunopathogenesis of Cutaneous T-Cell Lymphoma. Hemato,”Oncol. Clin. N. Amer.9:997-1010 (1995).
Rossiter H, et al., “Skin Disease-Related T-Cells Bind to Endothelial Selectins: Expression of Cutaneous Lymphocyte Antigen (CLA) Predicts E-Selectin But Not P-Selectin Binding,”Eur. J. Immuno.24:205-210 (1994).
Santamaria Babi LF, et al., “Circulating Allergen-Reactive T Cells from Patients With Atopic Dermatitis and Allergic Contact Dermatitis Express the Skin-Selective Homing Receptor, the Cutaneous Lymphocyte-Associated Antigen,”J. Exp. Med.181(5):1935-1940 (1995).
Sackstein R, et al., “A Hematopoietic Cell L-Selectin Ligand That is Distinct From PSGL-1 and Displays N-Glycan-Dependent Binding Activity,”Blood96:2765-2774 (2000).
Schmid K, et al., “Amino Acid Sequence of Human Plasma Galactoglycoprotein: Identity With the Extracellular Region of CD43 (Sialophorin),”Proc. Natl. Acad. Sci. U S A.89(2):663-667 (1992).
Sharma and Korytnyk, “Modifications at C-3 and C

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