Fluorinated erythromycin compounds and a process for preparation

Details Fluorinated erythromycin compounds and a process for preparation Fluorinated erythromycin compounds and a process for preparation

1982-11-22

1985-04-30

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 74, 536122, C07H 1704

Patent

active

045145628

ABSTRACT:
Fluorinated derivatives of erythromycins A, B, C and D, having antibiotic activity, are prepared, starting from 8,9-anhydroerythromycin 6,9-hemiacetals or their N-oxides, through the reaction with a compound capable of generating electrophilic reactive fluorine, the resulting reaction product undergoing thereafter a reduction, possibly together with a methylation, to the corresponding (8S)-8-fluoroerythomycins.

REFERENCES:
patent: 2812323 (1957-11-01), Flynn et al.
patent: 3674773 (1972-07-01), Kurath
Haynes et al., "Advances In Carbohydrate Chem.", vol. 10, pp. 207-213, 1955.
Hough et al., "Jour. Chem. Soc.", #20, pp. 2513-2517, 1972.

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