Fluorinated butyric acids and their derivatives as inhibitors of

Details Fluorinated butyric acids and their derivatives as inhibitors of Fluorinated butyric acids and their derivatives as inhibitors of

1998-03-09

2000-03-14

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514443, 514468, 514613, 514675, 514825, 514885, 514903, 548440, 548448, 548449, 548450, 548512, 549 43, 549 44, 549 48, 549460, 549461, 564189, 564300, 568306, 568326, A01N 4338

Patent

active

06037361&

ABSTRACT:
Fluorinated butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and stromelysin-1, and also collagenase, matrilysin, and MMP-13, and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.

REFERENCES:
patent: 4239765 (1980-12-01), Regel et al.
patent: 5627206 (1997-05-01), Hupe et al.

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