Fluorinated bile acid derivatives, processes for the preparation

Details Fluorinated bile acid derivatives, processes for the preparation Fluorinated bile acid derivatives, processes for the preparation

1990-04-09

1991-10-29

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

552550, 552551, A61K 31575, C07J 900

Patent

active

050617010

ABSTRACT:
A compounds of general formula I ##STR1## wherein R.sub.1 is hydrogen or hydroxy, and the hydroxy group at the 7-position can be either in .alpha. or .beta. configuration, are valuable in human therapy. Compounds I can be prepared by fluorination of the suitably protected 6-hydroxy-7-keto-derivatives.

REFERENCES:
patent: 4460509 (1984-07-01), Mosbach et al.
patent: 4545938 (1985-10-01), Mosbach et al.
patent: 4648995 (1987-03-01), Mosbach et al.
Hsia, et al., J. Biological Chem, 235 (7), 1960, pp. 1963-1967.

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