Fluorinated aromatic polyenes

Details Fluorinated aromatic polyenes Fluorinated aromatic polyenes

1978-10-18

1979-09-25

Niebling, John

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2604045, 260408, 260599, 560254, 542438, 568663, 568816, 546216, 546301, 424263, 424267, 42424854, 424308, 42424855, 424318, 424324, 424333, 424339, 424343, C09F 500, C11C 300, C09F 700, A01N 924

Patent

active

041691008

ABSTRACT:
Compounds represented by the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are lower alkyl, R.sub.4 is lower alkoxy, R.sub.6 and R.sub.8 are methyl or trifluoro methyl, R.sub.9 is formyl, hydroxymethyl, alkoxymethyl, alkanoyloxymethyl, carboxyl, alkoxycarbonyl, lower alkenoxycarbonyl, lower alkynoxycarbonyl, carbamoyl, mono(lower alkyl)-carbamoyl, di(lower alkyl)carbamoyl or N-heterocyclylcarbonyl, R.sub.5, R.sub.7, R.sub.10, R.sub.11, R.sub.12 and R.sub.13 are hydrogen or fluorine with the proviso that at least one of R.sub.5, R.sub.7, R.sub.10, R.sub.11, R.sub.12 or R.sub.13 is fluorine or at least one of R.sub.6 or R.sub.8 is trifluoro methyl, or pharmaceutically acceptable salts thereof useful as antitumor agents are disclosed.

REFERENCES:
patent: 3862969 (1975-01-01), Henrick

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