Fluorinated aromatic polyenes

Details Fluorinated aromatic polyenes Fluorinated aromatic polyenes

1980-11-12

1982-03-23

Niebling, John F.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C 6352

Patent

active

043212093

ABSTRACT:
Compounds represented by the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are lower alkyl, R.sub.4 is lower alkoxy, R.sub.6 and R.sub.8 are methyl or trifluoro methyl, R.sub.9 is formyl, hydroxymethyl, alkoxymethyl, alkanoyloxymethyl, carboxyl, alkoxycarbonyl, lower alkenoxycarbonyl, lower alkynoxycarbonyl, carbamoyl, mono(lower alkyl)-carbamoyl, di(lower alkyl)carbamoyl or N-heterocyclylcarbonyl, R.sub.5, R.sub.7, R.sub.10, R.sub.11, R.sub.12 and R.sub.13 are hydrogen or fluorine with the proviso that at least one of R.sub.5, R.sub.7, R.sub.10, R.sub.11, R.sub.12 or R.sub.13 is fluorine or at least one of R.sub.6 or R.sub.8 is trifluoro methyl, or pharmaceutically acceptable salts thereof useful as antitumor agents are disclosed.

REFERENCES:
patent: 3163669 (1964-12-01), Stilz
patent: 3657306 (1972-04-01), Murray
patent: 3862969 (1975-01-01), Henrick
patent: 3954817 (1976-05-01), Jager
Bollag et al., Chem. Abst. 82:11177x, (1975).
Ike et al., Bull. Chem. Soc., Jap., vol. 47, pp. 350-354, (1974).

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