Fluorinated aromatic polyenes

Details Fluorinated aromatic polyenes Fluorinated aromatic polyenes

1982-03-30

1983-03-01

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568655, 568495, 568415, C07C 49248, C07C 47263, C07C 4323

Patent

active

043755631

ABSTRACT:
Compounds represented by the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are lower alkyl, R.sub.4 is lower alkoxy, R.sub.6 and R.sub.8 are methyl or trifluoro methyl, R.sub.9 is formyl, hydroxymethyl, alkoxymethyl, alkanoyloxymethyl, carboxyl, alkoxycarbonyl, lower alkenoxycarbonyl, lower alkynoxycarbonyl, carbamoyl, mono(lower alkyl)-carbamoyl, di(lower alkyl)carbamoyl or N-heterocyclylcarbonyl, R.sub.5, R.sub.7, R.sub.10, R.sub.11, R.sub.12 and R.sub.13 are hydrogen or fluorine with the proviso that at least one of R.sub.5, R.sub.7, R.sub.10, R.sub.11, R.sub.12 or R.sub.13 is fluorine or at least one of R.sub.6 or R.sub.8 is trifluoro methyl, or pharmaceutically acceptable salts thereof useful as antitumor agents are disclosed.

REFERENCES:
patent: 3163669 (1964-12-01), Stilz
patent: 3193565 (1965-07-01), Tschesche
patent: 3281440 (1966-10-01), Machleidt
patent: 3657306 (1972-04-01), Murray
patent: 3840559 (1974-10-01), Hoffmann
patent: 3862969 (1975-01-01), Henrick
patent: 3896150 (1975-07-01), Hoffmann
patent: 3954817 (1976-05-01), Jager
patent: 4105681 (1978-08-01), Bollag et al.
Ike et al., Bull. Chem. Soc. Jap., vol. 47, pp. 350-354, (1974).
Derwent 26452x/15.

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