Fluorinated aromatic polyenes

Details Fluorinated aromatic polyenes Fluorinated aromatic polyenes

1979-05-10

1980-05-06

Niebling, John F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

562472, 562586, 560 62, 560183, 560184, C07C 4756, C07C 4944

Patent

active

042017270

ABSTRACT:
Compounds represented by the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are lower alkyl, R.sub.4 is lower alkoxy, R.sub.6 and R.sub.8 are methyl or trifluoro methyl, R.sub.9 is formyl, hydroxymethyl, alkoxymethyl, alkanoyloxymethyl, carboxyl, alkoxycarbonyl, lower alkenoxycarbonyl, lower alkynoxycarbonyl, carbamoyl, mono(lower alkyl)-carbamoyl, di(lower alkyl)carbamoyl or N-heterocyclylcarbonyl, R.sub.5, R.sub.7, R.sub.10, R.sub.11 R.sub.12 and R.sub.13 are hydrogen or fluorine with the proviso that at least one of R.sub.5, R.sub.7, R.sub.10, R.sub.11, R.sub.12 or R.sub.13 is fluorine or at least one of R.sub.6 or R.sub.8 is trifluoro methyl,
or pharmaceutically acceptable salts thereof useful as antitumor agents are disclosed.

REFERENCES:
patent: 3163669 (1964-12-01), Stilz
patent: 3657306 (1972-04-01), Murray
patent: 3862969 (1975-01-01), Henrick
patent: 3954817 (1976-05-01), Jager

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