Fluorinated arachidonic acid derivatives

Details Fluorinated arachidonic acid derivatives Fluorinated arachidonic acid derivatives

1991-06-24

1993-07-06

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514549, 514627, 548250, 548252, 560204, 560219, 564201, 564204, A61K 3141, A61K 3123, C07D25704, C07C 6736

Patent

active

052254291

ABSTRACT:
Fluorinated arachidonic derivatives are 5-lipoxygenase inhibitors which have the useful pharmacologic activity as antiallergy and anti-inflammatory agents and are useful for treating, for example, asthma, anaphylaxis, allergy, rheumatoid arthritis, and psoriasis and cardiovascular diseases.

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Stevenson, P. N., "Novel Strategies toward the synthesis of 10,10-Difluoroarachidonic Acid", University Microfilms Intl (1987).
Yoko Tanaka, et al., Archives of Biochemistry and Biophysics, vol. 263, No. 1, May 15, 1988, pp. 178-190.

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