Fluorinated arachidonic acid derivatives

Details Fluorinated arachidonic acid derivatives Fluorinated arachidonic acid derivatives

1991-08-05

1992-09-08

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514549, 514627, 548250, 548252, 560204, 560219, 564201, 564204, A61K 3141, A61K 3122, C07D25704, C07C 6736

Patent

active

051458616

ABSTRACT:
Fluorinated arachidonic derivatives are 5-lipoxygenase inhibitors which have the useful pharmacologic activity as antiallergy and anti-imflammatory agents and are useful for treating, for example, asthma, anaphylaxis, allergy, rheumatoid arthritis, and psoriasis.

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Pui-Yan Kwok, et al., Journal of the American Chemical Society 109, pp. 3684-3692, (1987).
Stevenson, Paul Nelson, Novel Stragegies toward the Synthesis of 10,10-Difluoroarachidonic Acid, A dissertation approved Feb. 13, 1987.
Yoko Tanaka, et al., Archives of Biochemistry and Biophysics, vol. 263, No. 1, May 15, 1988, pp. 178-190.
Y. Kobayashi, L'Actualite Chimique, pp. 181-182, May, 1987.

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