Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1981-08-21
1983-11-29
Shippen, Michael L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
564510, 424311, 424320, 424324, 424325, 424330, 560 39, 560 40, 560 41, 560169, 560170, 560172, 562444, 562448, 562449, 562561, 562565, 562574, 564155, 564159, 564164, 564165, 564170, 564182, 564183, 564185, 564196, 564197, 564198, 564209, 564220, 564224, 564367, C07C 8722, C07C 8728, C07C10124, A61K 3113
Patent
active
044180772
ABSTRACT:
Fluorinated aminobutyric acid and diaminobutane compounds in vivo are inhibitors of gamma-aminobutyric acid transaminase and have the following formula: ##STR1## wherein: Y represents hydrogen or fluorine;
REFERENCES:
patent: 3169133 (1965-02-01), Ayer
patent: 4134918 (1979-01-01), Bey
patent: 4264590 (1981-04-01), Chu
patent: 4326071 (1982-04-01), Bey
Silverman, Biochem., 15, pp. 4718-4723, (1976).
Walsh, "Enzyme-Activated Irreversible Inhibitors," pp. 177-185, (1978).
Bey Philippe
Gerhart Fritz
Jung Michel
Schirlin Daniel
Frankhouser David E.
McDonald Raymond A.
Merrell Toraude et Compagnie
Shippen Michael L.
Street Gary D.
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