Fluorinated amino acids

Details Fluorinated amino acids Fluorinated amino acids

1976-06-07

1977-06-07

Evans, Joseph E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10110

Patent

active

040284050

ABSTRACT:
Deutero analogs of 3-fluoro-D-alanine prepared by direct photofluorination of the D-amino acids demonstrate in vivo and in vitro antibacterial activity against both gram negative and gram positive microorganisms. Deuters analogs of 3-fluoro-L-alanine and 3-fluoro-D,L-alanine also demonstrate useful in vitro activity.

REFERENCES:
patent: 3839170 (1974-10-01), Kollonitsch
patent: 3956367 (1976-05-01), Kollonitsch
Rittenberg et al., "J. Biol. Chem.," vol. 125 (1938), pp. 1-12.
Yson et al., "Chem. Abstracts, " vol. 54 (1960), Cols. 12096-12098.
Lettre et al., "Chem. Abstracts, " vol. 68 (1968), 22229n.
Komkors et al., "Chem. Abstracts, " vol. 37 (1943), 4412.
Winnick et al., "Chem. Abstracts", vol. 58 (1960), Col. 8160.
Abstracts 100, 101, 102, 103, 15th Interscience Conf. on Antimicrobial Agents and Chemotherapy held in Washington D. C., Sept. 1975.

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