Fluorescently labeled microbeads

Details Fluorescently labeled microbeads Fluorescently labeled microbeads

1986-06-30

1987-10-13

Schofer, Joseph L.

Stock material or miscellaneous articles

Coated or structually defined flake, particle, cell, strand,...

Particulate matter

524458, 526201, 523223, 521 60, 521149, 525284, 525350, 525382, 525384, B32B 2730, C08K 501, C08K 502

Patent

active

046998284

ABSTRACT:
Highly uniform polymeric microbeads of a predetermined size, preferably having an attached fluorescent label on the surface, are prepared by causing seed particles to swell by absorption of a plurality of low molecular weight substances, at least one of which is a monomer having a reactive functional group. After absorption, the monomer is internally polymerized, and the reactive functional group is preferably reacted with a polyfunctional spacing agent thereby to provide a second reactive functional group. The latter is then reacted with a fluorescent label to provide the labeled microbead.

REFERENCES:
patent: 4247434 (1981-01-01), Vanderhoff et al.
patent: 4332694 (1982-06-01), Kalal et al.
patent: 4459378 (1984-07-01), Ugelstad

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