Fluorescent sensors for cellular amines

Details Fluorescent sensors for cellular amines Fluorescent sensors for cellular amines

2011-07-12

2011-07-12

Liu, Sue (Department: 1653)

Chemistry: analytical and immunological testing

Fluorescent dyes

Reexamination Certificate

active

07977120

ABSTRACT:
The invention provides compounds of formulas I, II, and III, methods of making them, and methods of their use. The compounds of the invention can be used as fluorescent sensors, for example, to detect an amine-containing analyte in a biological sample. The compounds can be selective for one type of amine over others and the amount of fluorescence can be correlated with the concentration of the amine in the sample.

REFERENCES:
patent: WO-2007016495 (2007-02-01), None
patent: WO-2007016495 (2007-02-01), None
Feuster, E. , et al., “Detection of Amines and Unprotected Amino Acids in Aqueous conditions by Formation of Highly Fluorescent Iminium Ions”,J. Am. Chem. Soc., 125, (2003),17174-16175.
Secor, K. , et al., “Fluorescent sensors for diamines”,Journal of Materials Chemistry,15(37), (2005),4073-4077.
Secor, K. , et al., “Selective Amine Recognition Development of a Chemosensor for Dopamine and Norepinephrine”,Department of Chemistry, 6(21), (2004),3727-3730.

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