Fluorescent sensor compounds for detecting saccharides

Details Fluorescent sensor compounds for detecting saccharides Fluorescent sensor compounds for detecting saccharides

2005-07-12

2005-07-12

Snay, Jeffrey R. (Department: 1743)

Chemistry: analytical and immunological testing

Biological cellular material tested

C436S064000, C436S094000, C436S095000, C436S172000

Reexamination Certificate

active

06916660

ABSTRACT:
Fluorescent sensor compounds having the formula:wherein L is selected from the group consisting of alkyl, alkylene, aryl, cycloalkyl, alkoxy, aryloxy, arylalkyl, and arylalkyloxyl;each m, m′, n, n′, p, and p′ is independently an integer from 0 to 4, inclusive; andeach R1, R′1, R2, R′2, R3and R′3is independently selected from the group consisting of hydrogen, alkyl, alkylene, aryl, cycloalkyl, alkoxy, aryloxy, arylalkyl, arylalkyloxyl, halo, substituted and unsubstituted amino, and substituted and unsubstituted thiol, are useful for the selective detection of saccharides such as glucose and sialyl Lewis X. The compounds find particular use in detecting saccharides in biological samples, and in detecting cancer cells that express cell surface polysaccharides such as sialyl Lewis X.

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