Chemistry: analytical and immunological testing – Peptide – protein or amino acid
Patent
1998-10-13
2000-11-21
Slobodyansky, Elizabeth
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
530350, G01N 3352, C07K 14435
Patent
active
06150176&
ABSTRACT:
Disclosed are fluorescent protein sensors for measuring the pH of a sample, nucleic acids encoding them, and methods of use. The preferred fluorescent protein sensors are variants of the green fluorescent protein (GFP) from Aequorea victoria. Also disclosed are compositions and methods for measuring the pH of a specific region of a cell, such as the mitochondrial matrix or the Golgi lumen.
REFERENCES:
Llopis et al. (Jun. 9, 1998) Proc. Natl. Acad. Sci. USA, vol. 95, pp. 6803-6808.
Kneen et al. (Mar. 1998) Biophysical J., vol. 74, pp. 1591-1599 (abstract).
Guttenplan et al. (1973) BBA, vol. 322, pp. 294-300 (abstract).0
Brejc et al. (1997) Proc. Natl. Acad. Sci. USA, vol. 94, pp. 2306-2311.
Llopis Juan
Remington S. James
Tsien Roger Y.
Wachter Rebekka M.
Haile Lisa A.
Slobodyansky Elizabeth
The Regents of the University of California
The State of Oregon acting by and through the State of Board of
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