Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2006-10-24
2006-10-24
Saeed, Kamal A. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C544S230000, C514S275000, C252S301160
Reexamination Certificate
active
07125996
ABSTRACT:
The invention provides methods relating to a novel screening assay format that can be applied to broad members of the protein kinase gene family. The assay uses a series of labeled, active site probes described herein that can be displaced by an inhibitor agent. The Kdfor the inhibitor compound is derived based on the Kdof the probe for the kinase and the dose response of the inhibitor agent. The invention also provides active site probes suitable for use with the screening method.
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Brown Martha Priscilla
Jakes Scott
Labadia Mark E.
Prokopowicz, III Anthony S.
Wildeson Jessi Marie
Boehringer Ingelheim Pharmaceuticals Inc.
Devlin Mary-Ellen M.
Dow David A.
Grazier Nyeemah
Morris Michael P.
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