Fluorescent probe for the quantitation of zinc

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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06903226

ABSTRACT:
A compound represented by general formula (IA) or a salt thereof useful as a fluorescent probe for zinc: wherein R1and R2represent a hydrogen atom or a group represented by formula (A), wherein X1, X2, X3, and X4represent a hydrogen atom, an alkyl group, a 2-pyridylmethyl group, or a protective group for an amino group, and m and n represent 0 or 1 provided that R1and R2do not simultaneously represent hydrogen atoms; R3and R4represent a hydrogen atom or a halogen atom; and R5and R6represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group, and R7represents a hydrogen atom or an alkyl group.

REFERENCES:
patent: 5874590 (1999-02-01), Nagano et al.
patent: 6201134 (2001-03-01), Nagano et al.
patent: 6441197 (2002-08-01), Nagano et al.
patent: 6469051 (2002-10-01), Nagano et al.
patent: 6525088 (2003-02-01), Nagano et al.
patent: 6569892 (2003-05-01), Nagano et al.
patent: 2000239272 (2000-09-01), None
Hirano T. et al., “Highly Zinc-Selective Fluorescent Sensor Molecules Suitable for Biological Applications”, J. Am. Chem. Soc., vol. 122, No. 49, Dec. 13, 2000, pp. 12399-12400.
Walkup G. K. et al., “A New Cell-Permeable Fluorescent Probe for Zn2+”, J. Am. Chem. Soc., vol. 122, No. 23, Jun. 14, 2000, pp. 5644-5645.
U.S. Appl. No. 10/204,417 filed Aug. 28, 2002 (National Stage of PCT/JP01/01504 filed Feb. 28, 2001) having the title “Agent for Measurement of Reactive Oxygen” (Applicants: Tetsuo Nagano et al.).
U.S. Appl. No. 10/204,418 filed Aug. 28, 2002 (National Stage of PCT/JP01/01502 filed Feb. 28, 2001) having the title Method for Measurement by Using Long- Lived Excitation Fluorescence (Applicants: Tetsuo Nagano et al.).
English Language Abstract of JP 2000-239272, published Sep. 5, 2000.
Handbook of Fluorescent Probes and Research Chemicals, 6th Edition by Richard P. Haugland, pp. 503 and 531-540 (1996).
Protective Groups in Organic Synthesis, T. W. Greene, John Wiley & Sons, Inc. pp. v-xxi and 369-405 (1981).
Angew. Chem., Int. Ed. (1999), 38(21), pp. 3209-3212.
Anal. Chem. (1998), 70(13), pp. 2446-2453.
Bioorganic & Medicinal Chemistry, vol. 4, No. 6, pp. 901-916, 1996.
Bioorg. Khim. (1995), 21(10), pp. 795-801.
Sci. China, Ser. B: Chem. (1998), 41(5), pp. 549-555.
J. Am. Chem. Soc. (1996), 118, pp. 6514-6515.
Reyes, J.G., et al., Biol. Res., 27, pp. 49-56, 1994.
Tsuda, M., et al., Neurosci., 17, pp. 6678-6684, 1997.
Koike, T., et al., J. Am. Chem. Soc., 118, pp. 12696-12703, 1996.
Saibou Kougaku (Cell Technology), 17, pp. 584-595, 1998.
Tanpakushitsu.Kakusan.Kouso (Protein, Nucleic Acid and Enzyme), extra No., 42, pp. 171-176, 1997.
Tetsuji Kametani, Nankodo Co., Ltd., p. 215, 1997.

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