Fluorescent polymeric sensor for the detection of creatinine

Chemistry: analytical and immunological testing – Heterocyclic carbon compound – Hetero-n

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436106, 436113, 436164, 436169, 436170, 436172, 436800, 422 55, 422 56, 422 8205, 422 8208, 422 8211, G01N 3300

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active

059587865

ABSTRACT:
The present invention provides a creatinine sensor material having a first layer of a protonated pH sensitive fluorophore immobilized in a hydrophobic polymer, wherein the fluorophore can react quantitatively with ammonia and the transducing moiety of the fluorophore is neutrally charged when deprotonated; a second layer of creatinine deiminase and a polymer; and a third layer of a polymer. The present invention also provides a method for detecting creatinine using the creatinine sensor material and optical sensing devices that incorporate the creatinine sensor material.

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