Fluorescent pH indicators

Details Fluorescent pH indicators Fluorescent pH indicators

1992-07-13

1994-04-12

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549227, C07D31190

Patent

active

053027310

ABSTRACT:
Fluorescent pH indicator compounds which exhibit an increase in fluorescence intensity with decreasing pH. The indicators are derivatives of rhodamine and sulforhodamine type dyes and are particularly useful for measuring pH in acidic environments such as carbon dioxide production by microorganisms and pH of certain acidic intracellular compartments.

REFERENCES:
patent: 4945171 (1990-07-01), Haugland
R. P. Haugland, 1989, "Molecular Probes Handbook," Molecular Probes, Inc., p. 30, Figs. 4,2 and 4.3; supra, pp. 86-88 and 93.
Graber et al., Anal. Biochem., 156, 202-212 (1986).
Kolber et al., J. Immunol. Mtds., 108, 225-264 (1988).

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