Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1996-07-10
2000-04-25
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530302, 530324, 435 71, C07K 700
Patent
active
060545577
ABSTRACT:
The invention provides biologically active compounds of the formula: ##STR1## where R.sub.1 is a light-emitting moiety and R.sub.7 is a peptide of between 2 and 200 amino acids. X is selected from the group including .dbd.O, .dbd.S, --OH, .dbd.C.tbd.O, .dbd.NH, --H, --OR, --NR, --R, --R.sub.3 R.sub.4, wherein each R, R.sub.4 and R.sub.3, independently, is H or a C1-C6 branched or unbranched, substituted or unsubstituted, alkyl. The compounds are both biologically active and optically detectable. The peptide is chemically attached to the light-emitting moiety at an amino acid position which is not involved in binding to the peptide's receptor. In this way, the peptide's affinity for its receptor is not significantly decreased, and the compound retains high biological activity and can be easily detected using standard optical means.
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Beaudet Alain
Desjardins Clarissa
Faure Marie-Pierre
Gaudriault Georges
Vincent Jean-Pierre
Advanced Bioconcept (1994) Ltd.
Muirheid C. Delacroix
Tsang Cecilia J.
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