Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heavy metal containing doai
Reexamination Certificate
2011-05-10
2011-05-10
Henley, III, Raymond J (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heavy metal containing doai
C427S002140, C977S701000, C977S712000, C977S715000
Reexamination Certificate
active
07939560
ABSTRACT:
Multifunctional “smart” nanostructures are disclosed that include fluorescein isothiocyanate (FITC)-encapsulated SiO2core-shell particles with a nanoscale ZnO finishing layer, wherein an outer ZnO layer is formed on the SiO2-FITC core. These ˜200 nm sized particles showed promise toward cell imaging and cellular uptake studies using the bacteriumEscherichia coliand Jurkat cancer cells, respectively. The FITC encapsulated ZnO particles demonstrated excellent selectivity in preferentially killing Jurkat cancer cells with minimal toxicity to normal primary immune cells (18% and 75% viability remaining, respectively, after exposure to 60 μg/mL) and inhibited the growth of both gram-positive and gram-negative bacteria at concentrations ≧250-500 μg/mL (forStaphylococcus aureusandEscherichia coli, respectively). These results indicate that the FITC encapsulated multifunctional particles with nanoscale ZnO surface layer can be used as smart nanostructures for particle tracking, cell imaging, antibacterial treatments and cancer therapy.
REFERENCES:
patent: 7241399 (2007-07-01), Haubold et al.
patent: 2009/0136580 (2009-05-01), Punnoose et al.
patent: 2009/0186419 (2009-07-01), Ying et al.
patent: WO 2009/039508 (2009-03-01), None
patent: WO 2009/079056 (2009-06-01), None
PCT International Search Report, PCT/US2008/077284, Sep. 1, 2009.
Wang, Wingett, Engelard, Feris, Reddy, Turner, Layne, Hanley, Bell, Tenne, Wang, Punnoose, “Fluorescent dye encapsulated ZnO particles with cell-specific toxicity for potential use in biomedical applications”, Journal of Material Science: Materials in Medicine (2009) 20:11-22, U.S., published online Jul. 24, 2008.
Hays, Reddy, Graces, Engelhard, Shutthanandan, Luo, Xu, Giles, Wang, Thevuthasa, Punnoose, “Effect of Co doping on the structural, optical and magnetic properties of ZnO nanoparticles”, Apr. 27, 2007, Journal of Physics: Condensed Matter (2007) 266203 (24pp), UK, published Jun. 7, 2007.
Reddy, Feris, Wingett, Hanley, Punnoose, “Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems”, Applied Physics Letters, May 24, 2007, 90, 213902, U.S.
Feris Kevin
Kongara Madhusudan R
Punnoose Alex
Wang Hua
Wingett Denise
Boise State University
Henley, III Raymond J
Pedersen Barbara S.
Pedersen Ken J.
Pedersen and Company, PLLC
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