Fluorescent nucleotides

Details Fluorescent nucleotides Fluorescent nucleotides

2006-09-19

2006-09-19

Fredman, Jeffrey (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024300, C435S006120, C514S112000, C514S222200

Reexamination Certificate

active

07109314

ABSTRACT:
According to the present invention, there is provided a fluorescent nucleotide represented by the formula: A-B-C,wherein A represents a residue of natural or synthetic nucleotide, oligonucleotide, polynucleotide, or derivative thereof, and binds to B at a base moiety in said residue; B represents a divalent linking group or a single bond; and C represents a monovalent group derived from a fluorescent dye having 0 or 1 sulfonic acid group or phosphoric acid group in a molecule. The present invention provides useful fluorescent nucleotides for labeling nucleic acids, specifically, fluorescent nucleotides of which uptake ratio is high in synthetic reaction of nucleic acids.

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