Fluorescent membrane intercalating probes

Details Fluorescent membrane intercalating probes Fluorescent membrane intercalating probes

2006-02-03

2008-12-09

Jones, D. L (Department: 1618)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Diagnostic or test agent produces in vivo fluorescence

C424S001110, C424S001650, C424S009100, C548S400000

Reexamination Certificate

active

07462347

ABSTRACT:
The invention relates to a family of cyanine dyes which fluoresce in the far red and near infra red wavelengths of the spectrum and preferably possess lipophilic side chains. The dyes of the invention are soluble in commercially available membrane staining vehicles, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well retained therein. Methods of using the dyes to detect stained cells both in vivo and in vitro are also disclosed.

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