Fluorescent-magnetic nanoparticles with core-shell structure

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

Reexamination Certificate

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C424S489000, C424S001290

Reexamination Certificate

active

10414571

ABSTRACT:
This invention comprises nanoparticles for use with biosensors. The nanoparticles have core/shell architecture. The nanoparticles can be detected by two means, magnetic and optical by virtue of the nanoparticles magnetic core and fluorescent semiconductor shell. Methods of making the nanoparticles and their composition are described.

REFERENCES:
patent: 6048515 (2000-04-01), Kresse et al.
patent: 6444143 (2002-09-01), Bawendi et al.
Everett Carpenter et al., U.S. Appl. No. 10/355,162, “Magnetic Nanoparticles Having Passivated Metallic Cores,” filed Jan. 31, 2003.
Everett Carpenter et al., U.S. Appl. No. 60/307,693, “Magnetic Nanoparticles,” filed Apr. 9, 2002.
Yongchi Tian et al., “Coupled Composite CdS-CdSe and Core-Shell Types of (CdS)CdSe and (CdSe)CdS,” J. Phys. Chem., 1996, 100, 8927-8939.
A. R. Kortan et al., “Nucleation and Growth of CdSe on ZnS Quantum Crystallite Seeds, and Vice Versa, in Inverse Micelle Media,” J. Am. Chem. Soc., 1990, 112, 1327-1332.

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