Fluorescent latices having very low detection thresholds for flu

Details Fluorescent latices having very low detection thresholds for flu Fluorescent latices having very low detection thresholds for flu

1994-10-07

1997-03-04

Green, Lora M.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is organic

436518, 436531, 436532, 436534, 436546, 436800, 436172, 25230116, 25230135, 2524081, 428402, G01N 33533

Patent

active

056078641

ABSTRACT:
Fluorescent latices, well suited for a wide variety of analytical techniques, comprise polymer particles having at least one hydrophobic fluorochrome encapsulated therein, notably at least one condensed polyaromatic compound or derivative thereof, or a tetraphenylporphine and/or organometallic complex thereof, and have a detection threshold for fluorescence which is less than or equal to 10.sup.-12 mol of particles per liter of latex.

REFERENCES:
patent: 4115535 (1978-09-01), Giaever
patent: 4127499 (1978-11-01), Chen et al.
Vener et al., Analytical Biochemistry 198 pp. 308-311 (1991) "A novel Approach to Nonradioactive Hybridization assay of Nucleic Acids Using Stained Latex Particles".
Aldrich Catalogue, pp. 1179-1180 (1992) Aldrich Chemical Company, Milwaukee, WI, USA.
Hemmila, Applications of fluorescence in immunoassays, pp. 131-135 (1991) John Wiley & Sons, Inc.
Maeda, Laser Dyes, pp. 133-149 (1984) Academic Press, Inc.

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