Fluorescent labeled nucleotide derivatives

Details Fluorescent labeled nucleotide derivatives Fluorescent labeled nucleotide derivatives

2007-12-25

2007-12-25

Riley, Jezia (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C546S023000, C546S024000, C546S113000, C430S056000, C544S232000, C544S277000, C435S006120, C435S091100

Reexamination Certificate

active

10821500

ABSTRACT:
Fluorescent labeled reporter compounds having a modified cyanine dye that is coupled to a nucleotide derivative through a linker are disclosed. The compounds are useful for nucleic acid sequence analysis. The fluorescent labeled reporter compounds are ring-locked cyanine dyes that are coupled to a nucleotide derivative, such as a modified DNA base, through a linker. These fluorescent labeled reporter compounds can be used as DNA chain-terminators in DNA synthesis to generate DNA fragments that are fluorescently-labeled at the 3′-terminal end of the DNA fragment.

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Flanagan, J.H., et al.,Bioconjugate Chem., 8:751-756 (1997).
CEQ™ 2000 Dye Terminator Cycle Sequencing, Beckman Coulter, Inc. (1999).

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