Fluorescent labeled nucleotide derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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Details

C546S023000, C546S024000, C546S113000, C430S056000, C544S232000, C544S277000, C435S006120, C435S091100

Reexamination Certificate

active

10821500

ABSTRACT:
Fluorescent labeled reporter compounds having a modified cyanine dye that is coupled to a nucleotide derivative through a linker are disclosed. The compounds are useful for nucleic acid sequence analysis. The fluorescent labeled reporter compounds are ring-locked cyanine dyes that are coupled to a nucleotide derivative, such as a modified DNA base, through a linker. These fluorescent labeled reporter compounds can be used as DNA chain-terminators in DNA synthesis to generate DNA fragments that are fluorescently-labeled at the 3′-terminal end of the DNA fragment.

REFERENCES:
patent: 5453505 (1995-09-01), Lee et al.
patent: 5571388 (1996-11-01), Patonay et al.
patent: 6002003 (1999-12-01), Shen et al.
patent: WO95/04747 (1995-02-01), None
patent: WO 01/85850 (2001-11-01), None
patent: WO 02/24815 (2002-03-01), None
Flanagan, J.H., et al.,Bioconjugate Chem., 8:751-756 (1997).
CEQ™ 2000 Dye Terminator Cycle Sequencing, Beckman Coulter, Inc. (1999).

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