Fluorescent ion-selective diaryldiaza crown ether conjugates

Details Fluorescent ion-selective diaryldiaza crown ether conjugates Fluorescent ion-selective diaryldiaza crown ether conjugates

1995-01-19

1996-05-14

Schilling, Richard L.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Polymers from only ethylenic monomers or processes of...

5262381, 5262382, 5262383, 527200, 527312, 528403, 528423, 530300, 530350, 536 173, 536 55, 536 551, 540467, 549223, 549224, 549227, C07D32100, C07D27308, G01N 3122, C08F 2608

Patent

active

055168647

ABSTRACT:
This invention describes novel sensors for ions that are based on the combination of xanthylium-based dyes with metal-binding N,N'-diaryldiaza crown ethers. These sensors are primarily useful for detection and quantitation of alkali-metal ions in aqueous solution. Binding of the ion results in a change in the fluorescence properties of the indicating dye that can be correlated with the ion concentration. Methods are provided for attaching reactive groups on these sensors for conjugation to dyes, lipids and polymers and for enhancing entry of the indicators into living cells.

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Yoshikami, et al., Biophys. J. 64, A221 (1993).

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