Fluorescent ion-selective diaryldiaza crown ether conjugates

Details Fluorescent ion-selective diaryldiaza crown ether conjugates Fluorescent ion-selective diaryldiaza crown ether conjugates

1993-03-29

1995-04-11

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540467, 549227, 422 8205, 422 8206, 422 8207, 422 8208, C07D32100, C07D27308, G01N 3122

Patent

active

054059755

ABSTRACT:
This invention describes novel sensors for ions that are based on the combination of xanthylium-based dyes with metal-binding N,N'-diaryldiaza crown ethers. These sensors are primarily useful for detection and quantitation of alkali-metal ions in aqueous solution. Binding of the ion results in a change in the fluorescence properties of the indicating dye that can be correlated with the ion concentration. Methods are provided for attaching reactive groups on these sensors for conjugation to dyes, lipids and polymers and for enhancing entry of the indicators into living cells.

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Bradshaw, et al., Synthesis of (Allyloxy)methyl-Substituted Diaza-18-crown-6 Compounds for Attachment to Silica Gel, J. Org. Chem., 53, 3190 (1988).
Hyashita, et al., Selective Column Concentration of Alkali-Metal Cations with a Crown Ether Carboxylic Acid Resin, Anal. Chem., 63, 1844 (1991).
Yoshikami, et al., Improved Methods for Labelling Cellular Aqueous Compartments with Fluorescent Polar Dyes, Biophys. J. 64, A221 (1993).

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