Fluorescent fused-ring traizoles that inhibit cell...

Details Fluorescent fused-ring traizoles that inhibit cell... Fluorescent fused-ring traizoles that inhibit cell...

2006-07-28

2009-10-06

Habte, Kahsay T (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S010000

Reexamination Certificate

active

07598238

ABSTRACT:
Fused-ring triazole compounds which inhibit proliferation of cells and exhibit a unique and intense fluorescence are provided. Also provided are methods for synthesizing these compounds and methods for using these compounds to inhibit cell proliferation and infection and to label and fluorescently detect selected molecules.

REFERENCES:
Cecil Textbook of Medicine (20th Edition, vol. 2, 1996, pp. 1739-1747).
Angibaud et al., “4-Methyl-1,2,4-triazol-3-y1 Heterocycle as an Alternative to the 1-Methylimidazol-5-y1 Moeity in the Farnesyltransferase Inhibitor Zarnestra”, Bioorganic & Medicinal Chemistry Letters 2003 13:4361-4364.
Catarzi et al., “Synthesis and Biological Evaluation of Analogues of 7-Chloro-4,5-dihydro-4-oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo [1,5-a]quinoxaline-2-carboxylic Acid (TQX-173) as Novel Selective AMPA Receptor Antagonists”, J. Med. Chem. 2004 47:262-272.
Demirbas et al., “Synthesis of 3-Alkyl(Ary1)-4-alkylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-ones and 3-Alkyl-4-alkylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones as Antitumor Agents”, Bioorganic & Medicinal Chemistry 2002 10:3717-3723.
Ikeda et al., “Synthesis of a novel histidine analogue and its efficient incorporation into a protein in vivo”, Protein Engineering 2003 16(9):699-706.
Torurirte et al., “Synthesis of 3′-deoxy-3′-[4-(pyrimidin-1-yl)methyl-1,2,3-triazol-1-yl] thymidine via 1,3-dipolar cycloaddition”, Nucleosides Nucleotides Nucleic Acids 2003 22 (11):1985-1993.
Pomarnacka et al., “Synthesis of 1-(6-chloro-1,1-dioxo-1,4,2-benzodithiazin-3-yl) semi-carbazides and their transformation into 4-chloro-2-mercapto-N-(4,5-dihydro-5-oxo-4-phenyl-1H-1,2,4-triazol-3-yl) benzenesulfonamides as potential anticancer and anti-HIV agents”, I1. 2003,58,423-9.
Reid et al., “Improved Syntheses of 5-Substituted-4-amino-3-mercapto-(4H)-1,2,4-triazoles”, J. Heterocyclic Chem. 1976 13:925-926.
Tominaga et al., “Early Phase II Study of the New Aromatase Inhibitor YM511 in Postmenopausal Patients with Breast Cancer. Difficulty in Clinical Dose Recommendation Based on Preclinical and Phase I Findings”, Anticancer Research 2003 23:3533-3542.
Weier et al., “Fish in cancer diagnosis and prognostication:from cause to course of disease”, Expert Rev. Mol. Diagn. 2002 2 (2):109-119.
Xu et al., “Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist”, J. Med. Chem. 2003 46:5121-5124.
Yurkow et al., “Mechanism of action of psoralens:isobologram analysis reveals that ultraviolet light potentiation of psoralen action is not additive but synergistic”, Cancer Chemother Pharmacol 1991 27:315-319.

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